GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs3749237 | 1 | rs11130216 | chr3:49736172 | CCDC36 | chr3:49235861-49295537:+ | 0.1 | 3.77 | 0.000175 | Resting heart rate |
| BRCA | cis | rs3749237 | 1 | rs11130216 | chr3:49736172 | DALRD3 | chr3:49052435-49058467:- | 0.13 | 4.42 | 1.1E-5 | Resting heart rate |
| BRCA | cis | rs3749237 | 1 | rs11130216 | chr3:49736172 | P4HTM | chr3:49027341-49044579:+ | 0.09 | 3.84 | 0.00013 | Resting heart rate |
| BRCA | cis | rs2130392 | 1 | rs11132254 | chr4:185611592 | CASP3 | chr4:185548852-185570629:- | 0.15 | 4.34 | 1.57E-5 | Kawasaki disease |
| BRCA | cis | rs2130392 | 1 | rs11132254 | chr4:185611592 | CCDC111 | chr4:185570767-185616112:+ | 0.16 | 4.49 | 7.85E-6 | Kawasaki disease |
| BRCA | cis | rs2130392 | 1 | rs11132254 | chr4:185611592 | IRF2 | chr4:185308878-185395726:- | 0.13 | 3.7 | 0.000224 | Kawasaki disease |
| BRCA | cis | rs2130392 | 1 | rs11132254 | chr4:185611592 | MLF1IP | chr4:185615220-185655286:- | -0.41 | -16.03 | 5.28E-52 | Kawasaki disease |
| BRCA | cis | rs1853207 | 1 | rs111485167 | chr10:96394254 | C10orf129 | chr10:96953957-96988685:+ | 0.34 | 5.4 | 8.04E-8 | Blood metabolite levels |
| BRCA | cis | rs111803315 | 1 | rs111489600 | chr14:59993021 | C14orf149 | chr14:59939406-59951126:- | -0.26 | -3.8 | 0.000153 | Schizophrenia |
| BRCA | cis | rs111803315 | 1 | rs111489600 | chr14:59993021 | JKAMP | chr14:59951161-59972080:+ | 0.32 | 5.6 | 2.76E-8 | Schizophrenia |
| BRCA | cis | rs10871290 | 1 | rs11149710 | chr16:74472546 | RFWD3 | chr16:74655298-74700779:- | 0.09 | 3.73 | 0.000198 | Breast cancer |
| BRCA | cis | rs1853207 | 1 | rs111501284 | chr10:96392063 | C10orf129 | chr10:96953957-96988685:+ | 0.34 | 5.4 | 8.04E-8 | Blood metabolite levels |
| BRCA | cis | rs4947019 | 1 | rs11153170 | chr6:109652528 | PPIL6 | chr6:109711419-109761990:- | 0.26 | 4.32 | 1.74E-5 | Hematological parameters |
| BRCA | cis | rs111547017 | 1 | rs111547017 | chr6:43341689 | ZNF318 | chr6:43278872-43337181:- | 0.19 | 3.94 | 8.67E-5 | Schizophrenia |
| BRCA | cis | rs4731120 | 1 | rs111563630 | chr7:123412203 | HYAL4 | chr7:123485223-123517529:+ | 0.29 | 4.11 | 4.29E-5 | Platelet count |